Publications

2025

Wu, C.-Y., Kupferschmid, A. C., Chen, L., McManus, A. J., Kivisäkk, P., Galler, J. A., Schwab, N. A., DesRuisseaux, L. A., Williams, V. J., Gerber, J., Riley, M., Young, C., Guzmán-Vélez, E., Dodge, H. H., Tanzi, R. E., Singer, C. M., & Arnold, S. E. (2025). Cognitive and Alzheimer's disease biomarker effects of oral nicotinamide riboside (NR) supplementation in older adults with subjective cognitive decline and mild cognitive impairment. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 11(1), e70023. https://doi.org/10.1002/trc2.70023

2024

Arnold, S. E., Hyman, B. T., Betensky, R. A., & Dodge, H. H. (2024). Pathways to personalized medicine—Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease. Alzheimer's & Dementia, 20(4), 7384–7394. https://doi.org/10.1002/alz.14063

Ford, C. T., Galler, J. A., He, Y., Young, C., Simpson, B. G. K., Wu, C.-Y., Pfaffenroth, J., Wah, E. S., Arnold, S. E., Dodge, H. H., Corkey, J. A., & Das, S. (2024). Using Apple Watches to monitor health and behaviors of individuals with cognitive impairment: A case series study. The Journals of Gerontology: Series A. Advance online publication. https://doi.org/10.1093/gerona/glae250

Wu, C. Y., Yu, K., Arnold, S. E., Das, S., & Dodge, H. H. (2024). Who benefited most from the Internet-based Conversational Engagement RCT (I-CONECT)? Application of the personalized medicine approach to a behavioral intervention study. The Journal of Prevention of Alzheimer's Disease. Advance online publication. https://doi.org/10.14283/jpad.2024.1

de Geus, M. B., Wu, C. Y., Dodge, H., Leslie, S. N., Wang, W., Lam, T. T., Kahle, K. T., Chan, D., Kivisäkk, P., Nairn, A. C., Arnold, S. E., & Carlyle, B. C. (2025). Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers. Neurology, 104(5), e213375.

Trombetta, B. A., Wu, C. Y., Kuo, E., de Geus, M. B., Dodge, H. H., Carlyle, B. C., Kivisakk, P., & Arnold, S. E. (2024). Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 10(1), e12440. https://doi.org/10.1002/trc2.12440

2023

Dodge, H. H., & Arnold, S. E. (2023). One step forward to personalized medicine?. Alzheimer's & dementia (New York, N. Y.), 9(4), e12435. https://doi.org/10.1002/trc2.12435

Schwab, N., Wu, C.-Y., Galler, J., DeRamus, T., Ford, A., Gerber, J., Kitchen, R., Rashid, B., Riley, M., Sather, L., Wang, X., Young, C., Yang, L., Dodge, H. H., & Arnold, S. E. (2023). Feasibility of common, enjoyable game play for assessing daily cognitive functioning in older adults. Frontiers in Neurology, 14, 1258216. https://doi.org/10.3389/fneur.2023.1258216

2021

Al Ali, J., Vaine, C. A., Shah, S., Campion, L., Hakoum, A., Supnet, M. L., Acuña, P., Aldykiewicz, G., Multhaupt-Buell, T., Ganza, N., Lagarde, J., De Guzman, J. K., Go, C., Currall, B., Trombetta, B., Webb, P. K., Talkowski, M., Arnold, S. E., Cheah, P. S., Ito, N., … Breakefield, X. O. (2021). TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism. Movement disorders: official journal of the Movement Disorder Society, 36(1), 206–215.

2020

Schwab, N. A., DesRuisseaux, L. A., Weinberg, M. S., & Arnold, S. E. (2020). Saving cognitive outcome data in Alzheimer's disease clinical trials during the COVID-19 pandemic: Commentary on the virtual administration of the ADAS-Cog. Alzheimer's & Dementia (New York, N. Y.), 6(1).

DesRuisseaux, L. A., Williams, V. J., McManus, A. J., Gupta, A. S., Carlyle, B. C., Azami, H., Gerber, J. A., Bolling, A. M., Cook, C. L., Betensky, R. A., & Arnold, S. E. (2020). A pilot protocol to assess the feasibility of a virtual multiple crossover, randomized controlled trial design using methylphenidate in mild cognitive impairment. Trials, 21(1), 1016.

Bryant, A. G., Hu, M., Carlyle, B. C., Arnold, S. E., Frosch, M. P., Das, S., Hyman, B. T., & Bennett, R. E. (2020). Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. Frontiers in neurology, 11, 575953.

Katsumi, Y., Racine, A. M., Torrado-Carvajal, A., Loggia, M. L., Hooker, J. M., Greve, D. N., Hightower, B. G., Catana, C., Cavallari, M., Arnold, S. E., Fong, T. G., Vasunilashorn, S. M., Marcantonio, E. R., Schmitt, E. M., Xu, G., Libermann, T. A., Barrett, L. F., Inouye, S. K., Dickerson, B. C., Touroutoglou, A., … RISE Study Group (2020). The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium. NeuroImage. Clinical, 27, 102346.

Vallabh, S. M., Minikel, E. V., Williams, V. J., Carlyle, B. C., McManus, A. J., Wennick, C. D., Bolling, A., Trombetta, B. A., Urick, D., Nobuhara, C. K., Gerber, J., Duddy, H., Lachmann, I., Stehmann, C., Collins, S. J., Blennow, K., Zetterberg, H., & Arnold, S. E. (2020). Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease. BMC medicine, 18(1), 140.

Weinberg, M. S., Patrick, R. E., Schwab, N. A., Owoyemi, P., May, R., McManus, A. J., Gerber, J., Harper, D. G., Arnold, S. E., & Forester, B. (2020). Clinical Trials and Tribulations in the COVID-19 Era. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 28(9), 913–920.

Arnold S. E. (2020). "Senior Moments" or More? Diagnostic Evaluation of Cognitive Complaints in Older Adults and the Role of Cerebrospinal Fluid Biomarkers. The journal of applied laboratory medicine, 5(1), 219–224. 3

2019

Vallabh, S. M., Nobuhara, C. K., Llorens, F., Zerr, I., Parchi, P., Capellari, S., Kuhn, E., Klickstein, J., Safar, J. G., Nery, F. C., Swoboda, K. J., Geschwind, M. D., Zetterberg, H., Arnold, S. E., Minikel, E. V., & Schreiber, S. L. (2019). Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development. Proceedings of the National Academy of Sciences of the United States of America, 116(16), 7793–7798.

Williams, V. J., Trombetta, B. A., Jafri, R. Z., Koenig, A. M., Wennick, C. D., Carlyle, B. C., Ekhlaspour, L., Ahima, R. S., Russell, S. J., Salat, D. H., & Arnold, S. E. (2019). Task-related fMRI BOLD response to hyperinsulinemia in healthy older adults. JCI insight, 5(14).

2018

Koenig, A. M., Nobuhara, C. K., Williams, V. J., & Arnold, S. E. (2018). Biomarkers in Alzheimer's, Frontotemporal, Lewy Body, and Vascular Dementias. Focus (American Psychiatric Publishing), 16(2), 164–172.

Carlyle, B. C., Trombetta, B. A., & Arnold, S. E. (2018). Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias. Proteomes, 6(3), 32.

Arnold, S. E., & Betensky, R. A. (2018). Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease. Annals of neurology, 84(2), 168–175.

Trombetta, B. A., Carlyle, B. C., Koenig, A. M., Shaw, L. M., Trojanowski, J. Q., Wolk, D. A., Locascio, J. J., & Arnold, S. E. (2018). The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease. PloS one, 13(3).

Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H. Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., Holtzman, D. M., & Nathan, D. M. (2018). Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nature reviews. Neurology, 14(3), 168–181.

2016

Koenig, A. M., Arnold, S. E., & Streim, J. E. (2016). Agitation and Irritability in Alzheimer's Disease: Evidenced-Based Treatments and the Black-Box Warning. Current psychiatry reports, 18(1), 3.